NAD+ Dosage Per Week: Your Complete Guide to Anti-Aging Supplementation

If you’ve been researching ways to boost energy, improve focus, or support healthy aging, chances are you’ve come across NAD+. But how much is the right amount, especially if you’re starting to feel the effects of age-related NAD+ decline?

Let’s break down the science, dosing strategies, and safe practices to help you make informed decisions about your NAD+ supplementation and figure out what is the right NAD+ Dosage Per Week for you.

What Is NAD+ and Why Does It Matter?

NAD+ (nicotinamide adenine dinucleotide) is a molecule found in every cell in your body. It plays a critical role in cellular energy production, DNA repair, and healthy aging. But here's the catch: as we age, our natural NAD+ levels decline.

For many adults, this decline can feel especially noticeable. Lower NAD+ levels have been linked to:

• Fatigue and brain fog

• Slower metabolism

• Reduced skin elasticity

• Poor sleep and recovery

  
  

Supplementing with NAD+ or its precursors (like NMN, NR, or NAM) can help replenish these levels, but only if taken correctly.

Overview of NAD+ Precursors

NAD+ precursors - NMN, NR, and NAM, are compounds that the body uses to produce NAD+ (nicotinamide adenine dinucleotide), a vital molecule for cellular metabolism, energy production, DNA repair, and the regulation of aging processes. As NAD+ levels decline with age, supplementing with these precursors is increasingly popular for supporting healthy aging.

NMN (Nicotinamide Mononucleotide)

Purpose: Directly supports NAD+ synthesis, energy metabolism, and cellular repair.

Benefits: Shown in animal and some human studies to improve cardiovascular health, insulin sensitivity, endurance, and possibly slow aging-related decline.

Use Cases: Anti-aging, metabolic health, cardiovascular support, and physical performance.

NR (Nicotinamide Riboside)

Purpose: Efficiently boosts NAD+ levels and supports enzymes involved in cellular repair and longevity.

Benefits: Well-researched for improving brain function (memory, learning), promoting heart health, reducing inflammation, and supporting muscle and metabolic health.

Use Cases: Cognitive health, anti-aging, heart health, and general wellness.

NAM (Nicotinamide)

Purpose: Supports NAD+ and NADPH production, involved in energy metabolism and DNA repair.

Benefits: Highly safe, even at high doses; used for skin health, chemoprevention of non-melanoma skin cancers, and treatment of dermatological conditions.

Use Cases: Skin health, cancer prevention, and general cellular repair.

How NAD+ Precursors Differ

• Structure & Pathway: NMN is a larger molecule and sits closer to NAD+ in the synthesis pathway. NR converts into NMN once inside the cell. NAM uses a less efficient salvage pathway.

• Efficacy & Tissue Targeting: NMN may be more tissue-specific, NR has great brain bioavailability, and NAM is safest but least effective for anti-aging.

• Clinical Evidence: NMN and NR are more researched for anti-aging and cognitive benefits, while NAM is better studied for skin health and safety.

  
  

Forms of NAD+ Supplements and Their Weekly Dosage

Before jumping into exact numbers, it’s important to know the various ways you can supplement NAD+. Each form has a different delivery method, absorption rate, and dosing protocol.

Oral Precursors (NMN, NR, NAM)

These are the most common forms you’ll find in capsules or powders.

Nicotinamide Riboside (NR)

• Typical Daily Dose: 250–500 mg

• Weekly Equivalent: 1,750–3,500 mg

  
  

Nicotinamide Mononucleotide (NMN)

• Typical Daily Dose: 250–900 mg

• Weekly Equivalent: 1,750–6,300 mg

  
  

Nicotinamide (NAM)

• Typical Daily Dose: 900–3,000 mg (lower end preferred)

• Weekly Equivalent: 6,300–21,000 mg

Editor’s Tip: Many adults may benefit from starting at the higher end of the lower range (e.g., 250–500 mg/day of NR or NMN), especially if experiencing fatigue or mental fog.

NAD+ Injections

These are often administered subcutaneously or intramuscularly for faster absorption.

• Typical Dose: 50–200 mg per injection

• Frequency: 1–3 times per week

• Weekly Equivalent: 50–600 mg

Example Protocol: Start with 10 units (0.1 mL or 20 mg) three times per week. Gradually increase to 50 units (0.5 mL or 100 mg) three times per week, as tolerated.

IV Therapy

Used in wellness clinics for deep cellular repair or rapid replenishment.

• Typical Dose: 500–1,500 mg per session

• Frequency: 1–2 times per week initially

• Weekly Equivalent: 500–3,000 mg

  
  

Maintenance: Once desired levels are reached, therapy may be reduced to once a month.

So What Is the Ideal NAD+ Dosage Per Week?

Depending on your method of supplementation and health goals, your ideal NAD+ dosage may vary:

Oral (NR/NMN): 1,750–3,500 mg per week

Injections: 50–600 mg per week

IV Therapy: 500–3,000 mg per week (for short-term regimens)

Start low, track how you feel, and increase gradually under professional supervision.

Who Needs More NAD+?

• Adults with chronic fatigue or low energy

• Those experiencing cognitive changes like brain fog

• Individuals recovering from stress, illness, or surgery

• Those aiming for healthy aging and longevity

  
  

Safety Considerations for Weekly NAD+ Dosage

Personalization Is Key

Dosage should consider your weight, activity level, and health status. Do not forget that timing is also important. Choosing when to take your NAD+ supplement can make a big difference in how you feel and how your body responds.

Always Consult Your Healthcare Provider

Especially if you have underlying health issues or take medications.

Be Aware of Side Effects

• Mild side effects may include nausea, flushing, or fatigue.

• Taking oral supplements with food can help reduce discomfort.

• Injections or IVs should always be administered by professionals.

Why Consistency Beats Intensity

Taking NAD+ consistently, rather than mega-dosing sporadically, tends to deliver better results. Your body needs regular fuel to rebuild, repair, and energize.

Aim to space out doses across the week rather than loading up all at once. For example, three smaller NAD+ injections per week may feel better than a single high dose.

Choosing the Right Product

• Third-Party Tested: Make sure supplements are certified for purity and potency.

• Bioavailable Forms: Look for NMN or NR from reputable companies.

• Minimal Fillers: Avoid products with artificial colors, preservatives, or unnecessary additives.

  
  

Final Thoughts

NAD+ can be a powerful ally if you're looking to feel sharper, more energetic, and more youthful. But the key lies in finding the right weekly dosage, and sticking with it.

For most people, the following weekly doses are a safe, effective place to start:

• 1,750–3,500 mg of oral NMN/NR, or

• 50–600 mg via injection, or

• 500–3,000 mg through IV therapy

  
  

Let your goals, symptoms, and how your body responds guide your NAD+ journey. And as always, work closely with a trusted healthcare provider to tailor a plan that fits your life, your body, and your needs.