NAD+ Injections Dosage Per Day: How Much Should You Really Take?
- Jennifer Gusto
- Apr 26
- 3 min read
Updated: 2 days ago

When considering your NAD+ injections dosage per day, it’s important to understand your body needs and personal tolerance. Few therapies are as buzzed-about as NAD+ injections, when it comes to optimizing energy, longevity, and overall cellular health, but one question remains crucial: what is the right NAD+ injections dosage per day to actually see results safely?
Let’s break down the science, clinical practices, and real-world guidelines behind NAD+ dosing - because getting it right matters more than ever.
What Is NAD+ and Why Should You Care?
NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme present in every living cell. It powers your metabolism, supports DNA repair, regulates your body's internal clock, and even influences how you age.
Here’s why NAD+ is non-negotiable for vibrant health:
Energy Metabolism: Converts food into cellular energy (ATP).
DNA Repair: Helps fix DNA damage and maintain genomic stability.
Gene Regulation: Activates sirtuins—proteins tied to longevity and resilience.
Circadian Rhythm Regulation: Keeps your sleep-wake cycles and metabolism in sync.
Immune Support: Strengthens your body's natural defenses against stress and disease.
Unfortunately, NAD+ levels naturally decline with age, leading to reduced energy, impaired cellular repair, and increased risk of chronic diseases. That’s where NAD+ supplementation steps in.
Understanding NAD+ Injections Dosage Per Day
The nad+ injections dosage per day you need depends heavily on your health goals, method of administration, and personal tolerance. Here’s what the clinical data says:
Subcutaneous Injections
Typical Dosage: 50–200 mg per injection
Frequency: 1–3 times per week
Start Low: Begin with 50 mg once weekly and titrate up based on tolerance.
Most protocols suggest a maximum of 200 mg weekly via subcutaneous injections to minimize risks like flushing, nausea, and injection site irritation.
IV Infusions
Typical Dosage: 500–1,500 mg per session
Frequency: Daily for 3–10 days (for intensive therapy), then maintenance doses monthly.
High-dose IV infusions are typically reserved for:
Addiction recovery
Cognitive enhancement
Severe NAD+ depletion
How to Personalize Your NAD+ Injections Dosage
Several factors influence the ideal NAD+ dosage:
Age and Health Status: Older adults and individuals with chronic conditions may need higher daily doses (100–300 mg).
Treatment Goals:
Anti-aging: 100–200 mg weekly via subcutaneous injections.
Cognitive performance: 100 mg 2–3 times weekly.
Addiction recovery: 500–1,000 mg IV daily for 7–10 days.
Form of Administration:
Subcutaneous vials typically provide 500–1,000 mg, diluted over 10 days.
Nasal sprays offer about 30 mg per spray.
Starting low and adjusting slowly is critical for safety and efficacy.
Safety First: Side Effects and Precautions
While NAD+ injections are generally well-tolerated, potential side effects include:
Flushing
Mild headaches
Localized redness or swelling at the injection site
Best Practices:
Begin with 50 mg doses to test tolerance.
Do not exceed 200 mg per subcutaneous injection or 1,500 mg for an IV session.
Avoid NAD+ therapy if you have a history of severe liver or kidney disease or cancer without consulting your doctor.
Summary Table: Recommended NAD+ Injections Dosage Per Day
Administration Method | Typical Dosage | Frequency | Clinical Notes |
---|---|---|---|
Subcutaneous Injection | 50–200 mg | 1–3 times weekly | Titrate dose gradually |
IV Infusion | 500–1,500 mg | Daily for 3–10 days, then monthly | Ideal for acute recovery |
Nasal Spray | 30 mg | Daily | Convenient for maintenance dosing |
Clinical Studies Supporting NAD+ Injection Protocols
Clinical research and wellness centers back these protocols:
Invigor Medical: Recommends daily doses of 100–300 mg for sustained NAD+ levels.
Regenics: Highlights the safety of 50–200 mg subcutaneous protocols.
Walnut Creek Aesthetics: Advises careful 4-week titration to monitor efficacy and side effects.
Jinfiniti: Encourages NAD+ blood testing to tailor dosing to personal needs.
Key Takeaway: The optimal nad+ injections dosage per day is a balance between health goals, clinical guidance, and personal response.
Final Thought: How Much NAD+ Is Right for You?
There’s no one-size-fits-all answer to the perfect NAD+ injections dosage per day. Whether you're chasing youthful energy, better cognitive clarity, or enhanced recovery, the key is starting low, titrating carefully, and consulting a knowledgeable healthcare provider.
For most, 50–200 mg per injection, once or twice weekly, is an excellent starting point for sustainable, noticeable benefits. More intensive regimens (500–1,500 mg IV) should always be monitored professionally.
Your cells and your future self will thank you!
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